Zika virus was first isolated in 1947 from a sicked-Rhesus monkey in Uganda. The first human isolation of Zika virus was reported in 1954 in Nigeria, during a yellow-fever outbreak with no feasible description of the clinical impact. Yap Islands (Federal States of Micronesia) reported the first large outbreak in 2007 that affected more than 75% of the local population. In 2013 and 2014, Zika virus outbreaks affected French Polynesia and many Pacific Islands (New Caledonia, the Cook Islands and Eastern Island), respectively. In mid-2015 the World Health Organization reported the most recent Zika virus outbreak in the Northeastern region of Brazil, which is still ongoing and that has affected more than 45 countries all over the world.